tadalafil 20mg 10 000 times more active blocks PDE5 FDE3 - an enzyme found in heart and blood vessels. This selectivity for PDE5 against Fdez is important because Fdez an enzyme that catalyses the reduction of the heart muscle. Additionally, tadalafil 20mg is approximately 700 times more potent for PDE5 than for FDE6 found in the retina and is responsible for fotoperedachu. Sildenafil is also the action of a 10 000 times more potent for PDE5 compared to the effect on FDE7 - FDE10. Cialis improves erection and the possibility of sex with success. Cialis potential drug is valid for 36 hours. The effect occurs within 16 minutes after taking the drug in the presence of sexual arousal.
tadalafil 20mg in healthy subjects produced no significant changes in systolic blood pressure compared to placebo in supine position (mean maximal decrease of 1, 6/0, 8 mm Hg art., Respectively) and standing (maximum average reduction 0, 2/4, 6 mm Hg. art, respectively). tadalafil 20mg does not cause significant changes in heart rate. tadalafil 20mg does not lead to changes in recognizing colors (blue / green) due to the low affinity for FDEB. Moreover, there is no effect of sildenafil on visual acuity, electroretinograms, the IOP and pupil size. In the study of sildenafil in men with a daily dose of 10 mg showed no clinically significant effect of drug concentration and the amount of sperm morphology and motility
The pharmacokinetic properties of
After oral administration of medicines Cialis is rapidly absorbed. The average concentration (Cmax) is achieved after the plasma approximately two hours after ingestion. The rate and extent of absorption of sildenafil are not dependent on food intake, and Cialis drug can be administered regardless of meals. Hours (morning or evening) had no clinically significant effect on the rate and extent of absorption.
tadalafil 20mg pharmacokinetics in healthy subjects are linear with respect to time and dose. In the dose range of 2, 5 and 20 mg of the area under the curve "concentration time" (AUC) increases proportionally with dose. Plasma equilibrium is reached within 5 days while taking the drug once a day. The pharmacokinetics of sildenafil in patients with impaired erectile function is similar to the pharmacokinetics of the drug in patients without erectile dysfunction.
The volume of distribution is approximately 63 liters, indicating that sildenafil is distributed in the body tissues. In therapeutic concentrations, 94% sildenafil to plasma proteins. The protein binding is not affected by kidney disease. In healthy people under the age of 0, 0005% of the administered dose found in semen.
tadalafil 20mg is predominantly metabolized by the isoenzyme (CYP) P450 3A4. The main metabolite is metilkateholglyukuronid. This metabolite is at least 13,000 times less potent than tadalafil 20mg for PDE5. Therefore, one can hardly assume that this metabolite has been observed in clinically significant.
In normal subjects, the rate of intake of tadalafil 20mg 2, 5 l / h, the mean half-life - 17.5 hours. Sildenafil is primarily excreted in the form of inactive metabolites, faeces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).